The Ipamorelin + CJC-1295 combination is the most widely used GH secretagogue stack in peptide research. The synergy between a GHRP (Ipamorelin) and a GHRH analog (CJC-1295) produces GH pulses that are 5–10x greater than either compound administered alone.
Why the Combination Works
CJC-1295 (No DAC) stimulates the GHRH receptor on pituitary somatotrophs, priming them for GH release. Ipamorelin simultaneously activates the ghrelin receptor (GHSR-1a), triggering the actual GH pulse. The two mechanisms are complementary — one opens the door, the other pushes through it.
The Protocol
| Compound | Dose | Timing | Notes |
|---|---|---|---|
| Ipamorelin | 200–300mcg | Before bed, fasted | 2+ hours post-meal |
| CJC-1295 No DAC | 100–200mcg | Same injection, before bed | Administer simultaneously |
Critical Timing Rules
Both compounds must be administered on an empty stomach. Insulin and elevated blood glucose blunt GH release — even a small carbohydrate load 1–2 hours before injection can reduce the GH pulse by 50–70%. The optimal window is 2+ hours after the last meal, or first thing in the morning before eating.
Cycle Length
Standard cycle: 8–12 weeks on, 4 weeks off. The off period prevents pituitary desensitization. IGF-1 levels typically peak at 4–6 weeks and plateau — the off period allows receptor sensitivity to reset. Many researchers run 2–3 cycles per year.